CASE STUDIES

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Case Study 1

INDUCTION OF FAT APOPTOSIS BY A NON-THERMAL DEVICE:
SAFETY AND MECHANISM OF ACTION OF NON-INVASIVE HIFEM®
TECHNOLOGY EVALUATED IN A HISTOLOGICAL PORCINE MODEL.

Conducted By

Robert Weiss M.D. (1), MVDr. Jan Bernardy (2)

(1) Maryland Laser Skin, & Vein Institute, Hunt Valley, MD; (2) Veterinary Research Institute, Brno, CZ

Presented at the Annual Meeting of the American Society for Laser Medicine and Surgery, 2018 Dallas, TX.

Highlights

• 92 % increase in average apoptotic levels in fat cells from 18.75 %
at baseline to 35.95 % 8 hours post 1 treatment (levels in the
control subject remained stable).
• The results show link between fat cells apoptosis and elevated
levels of free fatty acids released during supramaximal muscle
contractions induced by the treatment.
• Blood analysis confirmed a rapid metabolic reaction after
the treatment as supporting evidence of changes in the
subcutaneous fat tissue. No safety risks were identified.

Study Design

• Evaluation of changes in the levels of programmed cell death
of adipocytes in a porcine model in vivo following a single EMSCULPT®
treatment.
• Two Yorkshire pigs were treated for 30 minutes. One pig was recruited
as a control subject.
• Punch biopsy specimens of fat tissue together with blood samples
were taken before the treatment, after 1 hour and 8 hours posttreatment.
• TUNEL assay was applied on histological samples and the blood
samples were tested for biochemical and hematological parameters.

Results

The apoptotic index was calculated from 120 histological samples.
Data were statistically analyzed using rANOVA.
abdomen
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Case Study 2

CHANGES IN SUBCUTANEOUS ABDOMINAL FAT THICKNESS
FOLLOWING HIGH-INTENSITY FOCUSED ELECTRO-MAGNETIC (HIFEM®)
FIELD TREATMENTS: A MULTI CENTER ULTRASOUND STUDY.

Conducted By

Bruce Katz M.D. (1), Robert Bard M.D. (2), Richard Goldfarb M.D. (3), Aaron Shiloh M.D. (4), Dilyana Kenolova M.D. (5)

(1) Juva Skin and Laser Center, Manhattan NY, USA; (2) Bard Cancer Diagnostics, Manhattan, NY, USA; (3) Center
for SmartLipo & Plastic Surgery, Langhorne PA, USA; (4) Shiloh Vein and Aesthetic Institute, Philadelphia PA,
USA; (5) Dermasense Dermatology Clinic, Burgas, Bulgaria.

Presented at the Annual Meeting of the American Society for Laser Medicine and Surgery, 2018 Dallas, TX.

Highlights

• 33 patients received four 30-minute treatments and were
evaluated 1 month post application.
• Ultrasonography calculated fat thickness in multiple mesurement
points covering the whole abdomen.
• On average 19.0 % (4.4 mm) reduction of fat was observed.
The most significant reduction in fat (26.6 %) was observed
subumbilicaly.
• High consistency with 0 non-responders; 21 out of 33 patients
had greater than 15 % fat reduction.
• 91 % satisfaction with treatment results.

Results

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